I've had my PS3 crash/freeze a handful of times (at least once while playing inFamous), but never in the exact same spot. Make sure that you're connected to PSN and have the most up-to-date patch for the game.
Other than that, I think the freezing issues are more common with the 40GB and 60GB models.
I was about to ask what you're PC specs where.. *rolls eyes.* forgive me, St. Patricks day and all.
ANYWAYS. check you're disc, this sounds like a scratch, or, if the game requires a small install, the scratch on the disc c'aused a bad spot in the install, maybe try deleting JUST the game data.. not you're savegame!.