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Easter Eggs brought to you by 
Alternate ending
When on the bridge between the park and the lab, choose to jump off the bridge instead of pushing Nemesis off, it changes the end of the game along with other scenes through the rest of the game.
Director's Message
To read the director's message. beat the game 8 times. Note: this is the only chance you get to read it.
Resident Evil 2 Mr. X cameo
Near the end of the game where you fight the mutated version of Nemesis, look at the huge body near one of the batteries. This is the Mr. X tyrant from Resident Evil 2.