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A more useful cardboard box
When you're in the cave area with Meryl, hit her and quickly equip a cardboard box. She'll order a wolf to attack you, but if you're in a box, a wolf will pee on it instead. Now whenever that box is equipped the wolves will no longer attack you.
Cardboard Box Uses
You can use the cardboard boxes you find for transportation. Simply equip the cardboard box that corresponds with where you want to go (there are three boxes in total - one labeled 'Helipad,' one labeled 'Nuke Building,' and one labeled 'Snowfield') when you are inside the back of one of the parked trucks. Eventually, a guard will appear, and you will be transported to the area labeled on your box.
Control camera during briefing.
Select briefing from the main menu.Then press the LEFT TRIGGER or RIGHT TRIGGER to switch between 4 cameras.Use the analog stick or D-PAD to move the camera around.
Cutscene Zoom
During any cutscene you can zoom the camera in with the R button and move it around with the C-stick.
Easier ninja
While fighting the ninja throw a chaff grenade and he will freeze letting you hit him.Once you hit him he will falls to his knees and won't get up until all the yellow dust from the chaff grenade has fallen.
Easily cross mine fields.
If you want to easily cross mine fields, but you don't have the mine detector, just crawl on the ground where you believe mines are. Not only will receive no damage, but you'll also automatically collect all mines you crawl over!
Extra Damage to Ninja
If you have a weapon equipped and press "B" to punch Ninja, you'll deal extra damage to him. The nikita is the strongest, though it is very slow. FAMAS and Socom are the same speed, but the FAMAS is more powerful.
Higher Grip Lv.
When you hang from a ledge, do 100 pull ups (L + R). They have to be good pull ups. Grip Lv "3" is the maximum grip Lv.
Tip: In grip Lv1, you can only fit 4 good pull ups. Dont rush it. Once Snake does a good pull up let go of both buttoms, not just one.
Otacon's Ending
To view Otacon's Ending instead of Meryl's ending after completing the game, submit to Ocelot's torture after being captured.
Repel wolfs with sniper wolf hanky
when you go backtracking through the cavern after getting Sniper wolf's hanky. Equip it and the wolves think you're Sniper wolf and will appear to love you.
Replenish health during Ninja fight
When fighting the Ninja in the computer room, go to the top right corner of the room and shoot Mario on top of the computer to replenish your health. If you shoot Yoshi, you will hear his voice.
Spotting Mines without the Mine Detector
You can use the thermal goggles to actually see the mines.