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Name Party Members and some NPCs.
On the screen where you can select Issac's name press, Up, Down, Up, Down, Left, Right, Left, Right, Up, Right, Down, Left, Up, Select. You will now be able to name Garet, Ivan, Mia, Felix, Jenna, and Sheba, in addition to Issac.
Return to most recently visited sanctum
At the load file screen, press and hold L(shoulder),Start,and Select before loading the file. When the file is loaded, Isaac and company will be inside the most recently visited sanctum.