This is the traditional Western and Middle Eastern “Cradle of Civilization." It includes the Fertile Crescent, with the Nile River valley to the west and extending east down the Tigris and Euphrates river valleys to the Persian Gulf.
The Cradle of Civilization map packs are Firaxis-designed maps of real-world locations. You can play random leaders in these settings, or choose leaders appropriate to the history of these areas. The maps can also be opened up in World Builder, where you can even create specific scenarios.